|
KMID : 0370220090530010006
|
|
Yakhak Hoeji
2009 Volume.53 No. 1 p.6 ~ p.11
|
|
|
The Effect of Litsea japonica on the Apoptosis Induction of HL-60 Leukemia Cells
|
|
Kim Elvira
Boo Hye-Jin
Hyoun Jae-Hee
Kim Sang-Cheol
Kang Jung-Il
Kim Min-Kyoung
Yoo Eun-Sook
Kang Hee-Kyoung
|
|
|
Abstract
|
|
|
|
This study investigated the antiproliferative effect of the EtOH extract from Litsea japonica. The extract markedly inhibited the growth of HL-60 cells. When treated with the extract, several apoptosis events like as DNA fragmentation, chromatin condensation and the increase of the population of sub-G1 hypodiploid cells were observed. The extract decreased the Bcl-2 expression, whereas the Bax expression was increased. Caspase-9 and -3 were activated and poly (ADP-ribose) polymerase was cleaved. The results suggest that the antiproliferative effect of L. japonica in HL-60 appears to arise from apoptosis induction via the down-regulation of Bcl-2 and the activation of caspases.
|
|
|
KEYWORD
|
|
|
Litsea japonica, HL-60, apoptosis, Bcl-2, Bax, caspases
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|